Simulations of trabecular remodeling and fatigue : is remodeling helpful or harmful?
| Autor: | Rik Huiskes, Bert van Rietbergen, René F.M. van Oers, Keita Ito, Peter A. J. Hilbers |
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| Přispěvatelé: | Orthopaedic Biomechanics, Computational Biology |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Osteoblasts Histology Stress fractures Physiology business.industry Endocrinology Diabetes and Metabolism Osteoclasts Trabecular architecture medicine.disease Surgery Resorption Bone remodeling Regimen Internal medicine medicine Cardiology Computer Simulation Bone Remodeling Stress Mechanical business |
| Zdroj: | Bone, 48(5), 1210-1215. Elsevier |
| ISSN: | 1873-2763 8756-3282 |
| Popis: | Microdamage-targeted resorption is paradoxal, because it entails the removal of bone from a region that was already overloaded. Under continued intense loading, resorption spaces could potentially cause more damage than they remove. To investigate this problem, we incorporated damage algorithms in a computer-previous termsimulationnext term model for trabecular remodeling. We simulated damage accumulation and bone remodeling in a trabecular architecture, for two fatigue regimens, a ‘moderate’ regimen, and an ‘intense’ regimen with a higher number of loading cycles per day. Both previous termsimulationsnext term were also performed without bone remodeling to investigate if remodeling removed or exacerbated the damage. We found that remodeling tends to remove damage under the ‘moderate’ fatigue regimen, but it exacerbates damage under the ‘intense’ regimen. This harmful effect of remodeling may play a role in the development of stress fractures. |
| Databáze: | OpenAIRE |
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