APJ Is Associated with Treatment Response in Gastric Cancer Patients Receiving Concurrent Chemoradiotherapy and Endostar Therapy
| Autor: | Fang-ling Ning, Mianli Li, Yan-Zhang Hao, Xiu-Wen Wang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Pathology genetic structures Combination therapy Angiogenesis 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Distribution (pharmacology) Radiology Nuclear Medicine and imaging Receptor Lymph node Apelin receptor Pharmacology Apelin Receptors Neovascularization Pathologic business.industry Cancer Chemoradiotherapy General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Recombinant Proteins Endostatins Apelin 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female business |
| Zdroj: | Cancer Biotherapy and Radiopharmaceuticals. 32:133-138 |
| ISSN: | 1557-8852 1084-9785 |
| Popis: | Endostar combined with concurrent chemoradiotherapy (CRT) has been used in patients with gastric cancers (GCs). However, there are no reliable markers to predict the treatment response and prognosis of these patients. Apelin and its receptor (APJ) are involved in angiogenesis in tumor tissues. We aimed to study whether Apelin and Apelin receptor (APJ) tumor expression can predict the treatment response of combination therapy of endostar and CRT.We enrolled patients with locally advanced GC receiving CRT only and CRT+endostar combination therapy. Apelin receptor (APJ) in tumor samples was determined by immunohistological staining and scored by measuring staining area and signal intensity.The high APJ expression has significantly higher rates of tumor invasion, local lymph node, and distant metastasis (all p 0.001). In the CRT only group, the distribution of high and low APJ expression in patients with good and poor treatment response to CRT is not significantly different (p = 0.235). However, in the CRT+endostar group, the chance of having poor response to combined treatment is 3.645-fold higher in those having high APJ expression levels than those who have low APJ expression levels. Our prognostic analysis shows that in the CRT+endostar group, high APJ expression had significantly shorter overall survival (OS) period than those with low APJ expression (p 0.001). Furthermore, multivariate survival analysis reveals that the APJ expression is an independent predictor for the OS period in GC patients treated with CRT+endostar.Tumor APJ can be used to predict the therapy response and prognosis in GC patients receiving CRT+endostar therapy. |
| Databáze: | OpenAIRE |
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