The value of combined elevation of D-dimer and neopterin as a predictive parameter for early stage acute mesenteric ischemia: An experimental study

Autor: Ali Kagan Coskun, Ferhat Deniz, Yusuf Peker, Zekai Halici, Ali Harlak, Akgun Oral, Orhan Kozak, Taner Yigit, Yasin Bayir, Bilgehan Savas Oz, Öner Menteş, Tuncer Cayci
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
030204 cardiovascular system & hematology
Neopterin
Gastroenterology
Fibrin Fibrinogen Degradation Products
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Mesenteric Artery
Superior
Predictive Value of Tests
medicine.artery
Internal medicine
Laparotomy
Mesenteric Vascular Occlusion
Occlusion
D-dimer
medicine
Animals
Radiology
Nuclear Medicine and imaging
Superior mesenteric artery
Ligation
business.industry
General Medicine
medicine.disease
Up-Regulation
Disease Models
Animal
Early Diagnosis
ROC Curve
chemistry
Mesenteric ischemia
Area Under Curve
Mesenteric Ischemia
030220 oncology & carcinogenesis
Predictive value of tests
Anesthesia
Acute Disease
Surgery
Rabbits
Cardiology and Cardiovascular Medicine
business
Biomarkers
Zdroj: Vascular. 25:163-169
ISSN: 1708-539X
1708-5381
Popis: Background The diagnosis of acute mesenteric ischemia is variable. Early diagnosis is important for reducing the mortality and morbidity rates. Aim This experimental study aims to investigate the diagnostic utility of D-dimer and neopterin as a marker for the early stage of acute mesenteric ischemia caused by occlusion of superior mesenteric artery. Methods The levels of D-dimer and neopterin were measured using an animal acute mesenteric ischemia model in 21 male rabbits. Superior mesenteric artery occlusion (Group 1, n = 14) and control (Group 2, n = 7) groups were identified. Blood samples at different times are collected from each rabbits. Blood samples from superior mesenteric artery occlusion group were taken 30 min after anesthesia but before laparotomy, 1, 2, and 3 h after superior mesenteric artery ligation. Blood samples from control group were taken 1 h before, 1 and 3 h after anesthesia and laparotomy. The D-dimer and neopterin levels of each blood sample were measured. Results The probability of acute mesenteric ischemia was found to be 36 times higher when the D-dimer level was over 0.125 ng/L, whereas the probability was 19.2 times higher when the neopterin level was over 1.25 nmol/L. Conclusions In this experimental study, the combined elevation of two significant markers, D-dimer and neopterin, may be helpful for the early diagnosis of acute mesenteric ischemia.
Databáze: OpenAIRE
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