Incidence of Primary Ciliary Dyskinesia in Children with Recurrent Respiratory Diseases
| Autor: | Estelle Escudier, M Boucherat, Françoise Poron, André Coste, Marie-Claude Millepied, Philippe Reinert, C. Chapelin |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Recurrent respiratory tract infections Pathology medicine.medical_specialty Biopsy 03 medical and health sciences 0302 clinical medicine Recurrence otorhinolaryngologic diseases Humans Medicine Cilia Respiratory system Child 030223 otorhinolaryngology Respiratory Tract Infections Primary ciliary dyskinesia business.industry Incidence Incidence (epidemiology) Decision Trees General Medicine medicine.disease Otorhinolaryngology Dyskinesia El Niño 030220 oncology & carcinogenesis Etiology Female medicine.symptom business Ciliary ultrastructure Algorithms Ciliary Motility Disorders |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 106:854-858 |
| ISSN: | 1943-572X 0003-4894 |
| Popis: | The goal of the study was to evaluate the incidence of primary ciliary dyskinesia (PCD) in children suffering from recurrent respiratory tract infections (RRIs) by means of a noninvasive method. Respiratory ciliated cells were collected by nasal brushing in 118 children (4.6 ± 2.5 years) with RRIs. The ciliary beat frequency (CBF) was measured with a stroboscopic method, and when the CBF was abnormal, the ciliary ultrastructure was analyzed by a quantitative method. The CBF could be measured in 106 patients (90%) and was abnormal in 15 patients. The ciliary ultrastructure was found to be abnormal in 11 of 15 patients: PCD was diagnosed in 6 cases, and acquired ciliary defects were observed in the remaining 5 patients. Our conclusion, that PCD is rare but not exceptional (5.6%) in children with RRIs, justifies the systematic investigation of ciliated cells in such patients. For this purpose, nasal brushing can be used to sample ciliated cells even in young children. |
| Databáze: | OpenAIRE |
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