Mechanism of influence of molecular hydrogen on the function of the proximal tubule of the nephron in irritatable bowel syndrome

Autor: Yurii Rohovyi, Yula Bilooka, Vyacheslav Bilo’okiy, Ludmila Arkchipova, Volf Tsitrin
Rok vydání: 2021
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 11, Iss 2, Pp 53-62 (2021)
ISSN: 2391-8306
DOI: 10.12775/jehs.2021.11.02.006
Popis: Rohovyi Yurii, Tsitrin Volf, Bilooka Yula, Arkchipova Ludmila, Bilookiy Vyacheslav. Mechanism of influence of molecular hydrogen on the function of the proximal tubule of the nephron in irritatable bowel syndrome. Journal of Education, Health and Sport. 2021;11(2):53-62. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.2.006 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.2.006 https://zenodo.org/record/4540211 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 11.01.2021. Revised: 10.02.2021. Accepted: 15.02.2021. UDC: 612.466:616.613-002-007.271-07 MECHANISM OF INFLUENCE OF MOLECULAR HYDROGEN ON THE FUNCTION OF THE PROXIMAL TUBULE OF THE NEPHRON IN IRRITATABLE BOWEL SYNDROME Yurii Rohovyi1, Volf Tsitrin1, Yula Bilooka1, Ludmila Arkchipova2, Vyacheslav Bilookiy1 1Bukovinian State Medical University, Chernivtsi, Ukraine 2Regional municipal institution “Chernivtsi oblast clinical hospital”, Chernivtsi, Ukraine Yurii Rohovyi - Chief of the department pathological physiology the Bukovinian State Medical University, Chernivtsi, Ukraine. Volf Tsitrin – Postgraduate of the department pathological physiology the Bukovinian State Medical University, Chernivtsi, Ukraine. Yula Bilooka – Postgraduate of the department internal medicine and infectious diseases the Bukovinian State Medical University, Chernivtsi, Ukraine. Ludmila Arkchipova –– Physician reflexologist regional municipal institution “Chernivtsi oblast clinical hospital”, Chernivtsi, Ukraine. Vyacheslav Bilo’okiy –Professor of the Department of Surgery the Bukovinian State Medical University, Chernivtsi, Ukraine. Abstract Aim. To find out a pathophysiological protective role of influence of molecular hydrogen on a functional condition of a proximal tubule of kidneys at an irritable bowel syndrome. Materials and methods. 60 patients with irritable bowel syndrome were examined. Men - 18, women - 42 aged from 28 to 62 years. Of which: with irritable bowel syndrome with constipation were - 28 patients, irritable bowel syndrome with diarrhea - 32. The control group consisted of 25 almost healthy patients. General clinical (Likert scale), functional (proximal reabsorption of sodium ions in the kidneys), enzyme-linked immunosorbent assay (concentration of cytokines in blood plasma: tumor necrosis factor-a, interleukin-1β, interleukin-6), microbiological (рopulation levels of anaerobic B. Bifidum, B. lactis in lg CFO/g in the lumen of the colon), biochemical (the total, enzymatic fibrinolytic activity of urine) research methods were used. All patients received molecular hydrogen in the form of an aqueous solution in the amount of 1 liter per day in four doses of 250 ml for 7 days with a concentration of H2 1.0 - 1.2 ppm and redox potential from -250 to -350 mV, which was obtained using a generator of a new generation of antioxidant solution saturated with hydrogen Blue Water 900 (Korea), mode 1. Statistical data processing was performed using computer programs "Statgrafics" and "Exel 7.0". Results and discussion. The protective effect of molecular hydrogen improves the functional state of the proximal renal tubule in irritable bowel syndrome due to its high permeability and selective antioxidant activity against hydroxyl radical and peroxynitrite, which contributes to the rupture of large and small vicious circles in the combined pathological process. Key words: proximal tubule; water diuresis; renal function; molecular hydrogen; irritable bowel syndrome.
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