Cryosurgical ablation of liver tumors in colon cancer patients increases the serum total ganglioside level and then selectively augments antiganglioside IgM
| Autor: | Sakunthala Muthugounder, Anton J. Bilchik, Carlos A. Perez, Mepur H. Ravindranath, Thomas F. Wood, Donald L. Morton, Daniel Soh, Alexandra Gonzales |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Necrosis medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Adenocarcinoma Autoantigens Cryosurgery General Biochemistry Genetics and Molecular Biology Antibody Specificity Gangliosides Internal medicine Electrocoagulation Hepatectomy Homeostasis Humans Medicine Aged Autoantibodies Neoplasm Staging Aged 80 and over Ganglioside biology business.industry Liver Neoplasms Antibody titer General Medicine Middle Aged Radiofrequency Therapy Pathophysiology Cold Temperature Titer Endocrinology Immunoglobulin M Liver Colonic Neoplasms biology.protein Female Immunization Antibody medicine.symptom General Agricultural and Biological Sciences business Adjuvant Antiganglioside antibodies |
| Zdroj: | Cryobiology. 45:10-21 |
| ISSN: | 0011-2240 |
| DOI: | 10.1016/s0011-2240(02)00102-5 |
| Popis: | Cryosurgical ablation (CSA) of tumors induces disruptive necrosis. Necrosis may release tumor gangliosides into circulation and they may augment serum antiganglioside antibodies depending on the nature of gangliosides released. The hypothesis is tested by determining the level of serum total gangliosides (STG) and their antibody titers in the sera of colon cancer patients with cryoablated liver tumors. As controls, we examined the sera of patients who underwent radiofrequency ablation (RFA) and regular surgery (RS), none of which cause disruptive necrosis. The STG level (expressed as lipid-bound sialic acids, LBSA) is higher (p(2) |
| Databáze: | OpenAIRE |
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