Long-term Outcome and Causes of Death for Working-age Patients Hospitalized Due to Acute Pancreatitis With a Median Follow-up of 10 Years
| Autor: | Pasi Ohtonen, Janne Liisanantti, Heikki Karjula, Arto Saarela, Tero Ala-Kokko, Jyrki Mäkelä |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent 03 medical and health sciences Young Adult 0302 clinical medicine Median follow-up Internal medicine Cause of Death medicine Humans Young adult Working age Survival rate Cause of death Retrospective Studies business.industry Retrospective cohort study Middle Aged medicine.disease Hospitalization Survival Rate Treatment Outcome Pancreatitis 030220 oncology & carcinogenesis Etiology Acute pancreatitis 030211 gastroenterology & hepatology Surgery Female business Follow-Up Studies |
| Zdroj: | Annals of surgery. 269(5) |
| ISSN: | 1528-1140 |
| Popis: | OBJECTIVE To examine long-term survival and causes of death among working-age patients with acute pancreatitis (AP) compared with the normal population. SUMMARY OF BACKGROUND DATA Few studies have investigated long-term survival after AP and recurrent AP compared with the normal population; moreover, results from those studies are difficult to compare, due to suboptimal control populations and wide variations in follow-up times. METHODS This retrospective, registry-based study included 1644 patients with AP, aged 18 to 64 years, admitted to Oulu University Hospital in 1995 to 2012. Patient data were compared with data from 8220 age- and sex-matched controls that resided in the hospital district area. RESULTS Alcohol was the main etiologic factor causing 71.4% of the cases. During the median follow-up time of 9.5 years, mortality was 24.2% in the study group and 6.3% in the control group (P < 0.001). Alcohol-related factors caused 39.4% of deaths and alcohol AP was the main single cause of death (16.3%) in the study group. Of all fatal AP cases, 42.9% were related to recurrence. Survival was similar among patients with nonalcohol AP and controls. CONCLUSION The long-term mortality among patients admitted to the hospital due to (mainly alcohol induced) AP was 4 times higher than that in the age- and sex-matched control population. The significant difference in the causes of death between patients with alcohol AP and controls could be explained by alcohol-related diseases. Occurrences of AP without an alcohol etiology had a minimal impact on survival. |
| Databáze: | OpenAIRE |
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