Moody microbiome: Challenges and chances
| Autor: | Po-Hsiu Kuo, Yu-Chu Ella Chung |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Bipolar Disorder
Gut–brain axis Gut flora Bioinformatics digestive system 03 medical and health sciences 0302 clinical medicine medicine Humans Bipolar disorder Microbiome Randomized Controlled Trials as Topic lcsh:R5-920 Depressive Disorder Major biology Host Microbial Interactions business.industry Brain General Medicine medicine.disease biology.organism_classification Gastrointestinal Microbiome Clinical trial Mood 030220 oncology & carcinogenesis Antidepressant 030211 gastroenterology & hepatology medicine.symptom lcsh:Medicine (General) business Mania |
| Zdroj: | Journal of the Formosan Medical Association, Vol 118, Iss, Pp S42-S54 (2019) |
| ISSN: | 0929-6646 |
| Popis: | Growing evidence link gut microbiome to the development and maturation of the central nervous system, which are regulated by microbiota potentially through stress response, neurotransmitter, neuroimmune, and endocrine pathways. The dysfunction of such microbiota-gut-brain axis is implicated in neuropsychiatric disorders, depression, and other stress-related conditions. Using affective disorders as our primary outcomes, we inspect the current evidence of microbiota studies mainly in human clinical samples. Additionally, to restore microbiome equilibrium in bacteria diversity and abundance might represent a novel strategy to prevent or treat mood symptoms. We reviewed findings from clinical trials regarding efficacy of probiotics supplement with or without antidepressant treatment, and adjuvant antimicrobiotics treatment. In microbiota studies, the considerations of host-microbiota interaction and bacteria–bacteria interaction are discussed. In conclusion, the roles of microbiota in depression and mania state are not fully elucidated. One of the challenges is to find reliable targets for functional analyses and experiments. Notwithstanding some inconsistencies and methodological limitations across studies, results from recent clinical trials support for the beneficial effects of probiotics on alleviating depressive symptoms and increasing well-beings. Moreover, modifying the composition of gut microbiota via antibiotics can be a viable adjuvant treatment option for individuals with depressive symptoms. Keywords: Gut-brain axis, Depression, Microbiota, Mania, Bipolar disorder, Probiotics, Gene–microbiome interaction |
| Databáze: | OpenAIRE |
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