Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons
| Autor: | Ruobo Zhou, Boran Han, Xiaowei Zhuang, Chenglong Xia |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
MAPK/ERK pathway
Cell signaling congenital hereditary and neonatal diseases and abnormalities Primary Cell Culture Receptor tyrosine kinase Article Receptors G-Protein-Coupled Transactivation Mice Receptor Cannabinoid CB1 Animals Spectrin skin and connective tissue diseases Extracellular Signal-Regulated MAP Kinases G protein-coupled receptor Neurons Multidisciplinary biology Cell adhesion molecule Chemistry Calpain Cell Membrane nutritional and metabolic diseases Receptor Protein-Tyrosine Kinases Actins CD56 Antigen Cell biology Molecular Imaging Enzyme Activation Protein Transport Proteolysis biology.protein Signal transduction Cell Adhesion Molecules Signal Transduction |
| Zdroj: | Science (New York, N.Y.). 365(6456) |
| ISSN: | 1095-9203 |
| Popis: | A dynamic signaling scaffold In neurons, many cellular processes are regulated by receptor tyrosine kinases (RTKs), cell surface receptors whose activation can depend on other signaling pathways. Zhou et al. used super-resolution imaging to visualize colocalization of signaling proteins on the membrane-associated periodic skeleton (MPS) that is formed by actin, spectrin, and related molecules in the axons and dendrites of neurons. The colocalization of signaling proteins in different pathways leads to transactivation of RTK, which initiates intracellular signaling. In a negative feedback loop, the downstream signaling in turn leads to degradation of the MPS. Thus, the MPS is a dynamically regulated platform that coordinates signal transduction in neurons. Science , this issue p. 929 |
| Databáze: | OpenAIRE |
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