Early-life exposure to antibiotics and subsequent development of atopic dermatitis
| Autor: | Anna Cantarutti, Claudio Barbiellini Amidei, Andrea Stella Bonaugurio, Paola Rescigno, Cristina Canova |
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| Přispěvatelé: | Cantarutti, A, Amidei, C, Bonaugurio, A, Rescigno, P, Canova, C |
| Rok vydání: | 2022 |
| Předmět: |
atopic dermatiti
atopic dermatitis Infant Dermatitis birth cohort General Medicine early exposure Dermatiti Atopic Dermatitis Atopic Anti-Bacterial Agents Cohort Studies antibiotic exposure Risk Factors Humans Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Child Proportional Hazards Models |
| DOI: | 10.6084/m9.figshare.20115297.v1 |
| Popis: | Background: Antibiotic exposure may be associated with atopic dermatitis (AD). We assessed the risk of developing AD among children early exposed to antibiotics. Research design and methods: From the Italian Pedianet database, children aged 0-14 years between 2004-2017 were enrolled from birth up to at least one year. Cox proportional-hazards models were fitted to estimate Hazard Ratios (HR) and 95% Confidence Intervals (CI) for the association between antibiotic exposure during the first year of life with incident AD. Exposure was also considered as a time-varying variable. Results: 73,816 children were included in the final cohort, of which 34,202 had at least one antibiotic prescription. Incident AD was present in 8% of unexposed and exposed children. Early antibiotic exposure was not associated with any excess risk of AD compared to unexposed children (HR: 1.02, 95% CI: 0.97-1.07), and no dose-response effect was observed. In the time-varying analysis, antibiotic exposure was significantly associated with AD onset (1.12, 1.07-1.17). However, when taking into account the time-lag between exposure and outcome, risks progressively decreased, suggesting possible protopathic bias. Conclusion: These results are not suggestive of any significant association between exposure to antibiotics and subsequent AD onset and support the possible presence of protopathic bias. |
| Databáze: | OpenAIRE |
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