Integrating pharmacokinetics and pharmacodynamics in operational research to end tuberculosis
| Autor: | Giovanni Battista Migliori, Charles A. Peloquin, Helen McIlleron, Scott K. Heysell, Tawanda Gumbo, Andre Zagorski, Denise Rossato Silva, Jan-Willem C. Alffenaar, Daniela Maria Cirillo, Kelly E. Dooley |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Operations Research Tuberculosis therapeutic drug monitoring 030106 microbiology Antitubercular Agents Therapeutic drug monitoring law.invention 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Multidisciplinary approach law medicine pharmacodynamics Humans Tuberculose 030212 general & internal medicine Prospective Studies Disease Elimination Intensive care medicine Resistência a medicamentos Clinical pharmacology drug resistance medicine.diagnostic_test business.industry medicine.disease Medical research Monitoramento de medicamentos Viewpoints Infectious Diseases AcademicSubjects/MED00290 tuberculosis Farmacocinética Pharmacodynamics Drug resistance business pharmacokinetics |
| Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| Popis: | Tuberculosis (TB) elimination requires innovative approaches. The new Global Tuberculosis Network (GTN) aims to conduct research on key unmet therapeutic and diagnostic needs in the field of TB elimination using multidisciplinary, multisectorial approaches. The TB Pharmacology section within the new GTN aims to detect and study the current knowledge gaps, test potential solutions using human pharmacokinetics informed through preclinical infection systems, and return those findings to the bedside. Moreover, this approach would allow prospective identification and validation of optimal shorter therapeutic durations with new regimens. Optimized treatment using available and repurposed drugs may have an increased impact when prioritizing a person-centered approach and acknowledge the importance of age, gender, comorbidities, and both social and programmatic environments. In this viewpoint article, we present an in-depth discussion on how TB pharmacology and the related strategies will contribute to TB elimination. An enhanced understanding of tuberculosis (TB) pharmacology aims to use pharmacokinetics and pharmacodynamics, operational research, and therapeutic drug monitoring to support TB elimination. |
| Databáze: | OpenAIRE |
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