The efficacy of initial hydrocortisone administration at preventing posttraumatic distress in adult trauma patients: a randomized trial
| Autor: | Beth Fischer, John Bon, Adam Morris, Sarah A. Ostrowski, William F. Fallon, Douglas L. Delahanty, Nicole R. Nugent, Crystal A. Gabert-Quillen, Roger K. Pitman |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Poison control Placebo Article law.invention Stress Disorders Post-Traumatic Double-Blind Method Randomized controlled trial Quality of life Risk Factors law Internal medicine medicine Humans Depression (differential diagnoses) business.industry Middle Aged Psychiatry and Mental health Distress Treatment Outcome Traumatic injury Anti-Anxiety Agents Physical therapy Female Neurology (clinical) business Psychopathology |
| Zdroj: | CNS Spectrums. 18:103-111 |
| ISSN: | 2165-6509 1092-8529 |
| DOI: | 10.1017/s1092852913000096 |
| Popis: | Objective/IntroductionSecondary pharmacological interventions have shown promise at reducing the development of posttraumatic stress disorder symptoms (PTSS) in preclinical studies. The present study examined the preliminary efficacy of a 10-day low-dose (20 mg bid) course of hydrocortisone at preventing PTSS in traumatic injury victims.MethodsSixty-four traumatic injury patients (34% female) were randomly assigned in a double-blind protocol to receive either a 10-day course of hydrocortisone or placebo initiated within 12 hours of the trauma. One-month and 3-months posttrauma participants completed an interview to assess PTSS and self-report measures of depression and health-related quality of life.ResultsHydrocortisone recipients reported fewer PTSD and depression symptoms, and had greater improvements in health-related quality of life during the first 3 months posttrauma than did placebo recipients. Hydrocortisone recipients who had never received prior mental health treatment had the lowest PTSD scores.ConclusionLow-dose hydrocortisone may be a promising approach to the prevention of PTSD in acutely injured trauma patients, and may be particularly efficacious in acutely injured trauma victims without a history of significant psychopathology. |
| Databáze: | OpenAIRE |
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