Notch signalling in the regulation of peripheral T-cell function
| Autor: | Margaret J. Dallman, Emmanuel Briend, Lesley Lynn Young, Jonathan R. Lamb, Grahame J. Mckenzie, Brian R. Champion |
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| Rok vydání: | 2003 |
| Předmět: |
Receptors
Notch T-Lymphocytes Cellular differentiation T cell Regulator Notch signaling pathway Membrane Proteins Cell Differentiation Receptors Cell Surface Context (language use) Cell Biology Cell fate determination Biology Ligands Models Biological Cell biology Immune system medicine.anatomical_structure Immune Tolerance medicine Animals Receptor Signal Transduction Developmental Biology |
| Zdroj: | Seminars in Cell & Developmental Biology. 14:127-134 |
| ISSN: | 1084-9521 |
| Popis: | The Notch signalling pathway plays a highly-conserved role in regulating the cellular differentiation and proliferation events that characterise pattern formation in the embryo. As cells in the embryo respond to environmental signals, similarly T-cells in the peripheral immune system must monitor their environment for antigens and respond accordingly by entering one of several potential differentiation pathways. Recent studies have identified a role for the Notch pathway in regulating the responses of T-cells in the periphery. In this review, we discuss these findings in the context of the Notch signalling pathway's role as an orchestrator of cellular differentiation, and propose a central role for Notch as a regulator of immune system function. |
| Databáze: | OpenAIRE |
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