Cytochrome C Oxidase in rat adrenal and liver: Effects of anti-androgen treatment and studies in testicular feminized rats
| Autor: | Samuel Gallant, Josephine Alfano, Alexander C. Brownie, Fayig El-Migdadi |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Blotting Western Anti-Androgen Biology urologic and male genital diseases Flutamide Electron Transport Complex IV Rats Sprague-Dawley chemistry.chemical_compound Endocrinology Internal medicine Male rats medicine Animals Cytochrome c oxidase RNA Messenger Normal female Adrenal cortex Androgen Antagonists General Medicine Androgen-Insensitivity Syndrome Blotting Northern Androgen Rats Androgen receptor medicine.anatomical_structure Liver chemistry Adrenal Cortex biology.protein Female |
| Zdroj: | Endocrine Research. 22:59-75 |
| ISSN: | 1532-4206 0743-5800 |
| DOI: | 10.3109/07435809609030498 |
| Popis: | The role of androgen receptors in androgen-induced changes in rat adrenocortical and liver cytochrome c oxidase (COX) has been investigated. The anti-androgen, flutamide, blunted the increase in COX activity and COX subunits II/III and IV, that is seen with androgen treatment. Testicular feminized (Tfm) rats had levels of COX activity and COX subunits II/II and IV in adrenal cortex and liver that were intermediate between the high levels found in normal male rats and the lower levels of normal female rats. These data suggest that androgen effects on adrenal and liver COX are mediated through interactions with androgen receptors known to be present in these tissues. However, the observed changes in COX activity and COX subunits were not accompanied by altered levels of mRNAs encoding for COX II or COX IV. |
| Databáze: | OpenAIRE |
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