Role of Monocytes and Intestinal Macrophages in Crohn's Disease and Ulcerative Colitis
| Autor: | Susanne T. Gren, Olof Grip |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Chemokine Proteases CD14 Phagocytosis Monoblast Biology Monocytes 03 medical and health sciences 0302 clinical medicine Immune system Crohn Disease medicine Immunology and Allergy Animals Homeostasis Humans Crohn's disease U937 cell Macrophages Toll-Like Receptors Gastroenterology medicine.disease Immunity Innate Gastrointestinal Tract 030104 developmental biology Phenotype 030220 oncology & carcinogenesis Immunology biology.protein Colitis Ulcerative |
| Zdroj: | Inflammatory bowel diseases. 22(8) |
| ISSN: | 1536-4844 |
| Popis: | Monocytes and macrophages are part of the body's first line of defence, eliminating pathogens by phagocytosis or by releasing a broad array of inflammatory mediators, such as cytokines, chemokines, and proteases. In humans, 3 subsets of monocytes are described in blood with seemingly different functions, the classical (CD14CD16) monocytes, the intermediate (CD14CD16) monocytes, and the nonclassical (CD14CD16) monocytes. In the intestine, macrophages can be divided into resident and inflammatory macrophages that are distinguished by low and high expression of CD14, respectively. However, the roles and function of the 3 monocyte subsets in health and disease are not fully understood. In this review, we describe what is known about the origin of human intestinal macrophages and their blood monocytic counterparts and many of their numerous distinct mechanisms influencing the intestinal immune system. |
| Databáze: | OpenAIRE |
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