Thrombocytopenia represents a risk for deterioration of liver function after radiofrequency ablation in patients with hepatocellular carcinoma
| Autor: | Dong Wook Lee, Min Kyu Jung, Hyun Seok Lee, Chang Min Cho, Won Young Tak, So-Young Choi, Young Oh Kweon, Hyun Gu Park, Sung Kook Kim, Seong Woo Jeon, Soo-Young Park |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular Radiofrequency ablation Serum albumin Down-Regulation Gastroenterology Severity of Illness Index law.invention law Risk Factors Internal medicine medicine Odds Ratio Humans Risk factor lcsh:RC799-869 Molecular Biology Serum Albumin Aged Retrospective Studies Prothrombin time Aged 80 and over Hepatology biology medicine.diagnostic_test business.industry Liver Neoplasms Albumin Bilirubin Middle Aged medicine.disease Thrombocytopenia Surgery surgical procedures operative Hepatocellular carcinoma biology.protein Catheter Ablation Prothrombin Time Thrombocytopenia Liver function Original Article Female lcsh:Diseases of the digestive system. Gastroenterology Liver function Complication business therapeutics |
| Zdroj: | Clinical and Molecular Hepatology, Vol 18, Iss 3, Pp 302-308 (2012) Clinical and molecular hepatology |
| ISSN: | 2287-2728 |
| Popis: | Background/Aims: We evaluated changes in liver function parameters and risk factors for the deterioration of liver function 12 months after percutaneous radiofrequency ablation (RFA) therapy in patients with hepatocellular carcinoma (HCC). Methods: The subjects in this retrospective study comprised 102 patients with HCC who had undergone RFA therapy and exhibited no recurrence of HCC 12 months thereafter. Serial changes in serum total bilirubin and albumin, prothrombin time, and Child-Pugh score were evaluated before RFA and 3, 6, 9, and 12 months thereafter. Deterioration of liver function was defined when the Child-Pugh score increased by at least 2 at 12 months after RFA therapy. We determined the factors related to aggravation of liver function after RFA therapy. Results: Liver function had deteriorated 12 months after RFA in 29 patients (28.4%). Serum albumin levels decreased significantly from before (3.7±0.1 g/dL, mean±SD) to 12 months after RFA therapy (3.3±0.1 g/dL, P =0.002). The Child-Pugh score increased significantly during the same time period (from 6.1±0.2 to 7.2±0.3, P |
| Databáze: | OpenAIRE |
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