Stimulatory effect of curcumin on osteoclast apoptosis
| Autor: | Ken Ozaki, Y Kawata, Shigemasa Hanazawa, Shigeru Amano |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
musculoskeletal diseases
Curcumin Osteoclasts Apoptosis Stimulation In Vitro Techniques Biology Biochemistry Bone resorption chemistry.chemical_compound Osteoclast medicine Animals Bone Resorption Transcription factor Pharmacology Activator (genetics) Anti-Inflammatory Agents Non-Steroidal medicine.anatomical_structure chemistry Cancer research DNA fragmentation Rabbits |
| Zdroj: | Biochemical Pharmacology. 59:1577-1581 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/s0006-2952(00)00277-x |
| Popis: | Curcumin is a potent inhibitor of the transcriptional factors activator protein-1 and nuclear factor-kappaB. Since transcriptional factors may play a functional role in the survival of osteoclasts, it was of interest to us to examine the effect of curcumin on osteoclast apoptosis. We observed that curcumin is a potent stimulator of this process in rabbit osteoclasts, as evidenced by morphological changes in nuclei and DNA fragmentation as criteria of apoptosis. The curcumin stimulation of the osteoclast apoptosis was dose-and treatment time-dependent. In addition, curcumin dramatically inhibited osteoclastic bone resorption, supporting our data that curcumin is a potent stimulator of osteoclast apoptosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect