Decreased Serum Tryptophan in Patients with Cancer Cachexia Correlates with Increased Serum Neopterin
| Autor: | Noriaki Tanaka, Akio Hizuta, Hiromi Iwagaki, K. Orita |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Cachexia medicine.medical_treatment Immunology Endogeny Neopterin chemistry.chemical_compound Internal medicine medicine Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Aged Gastrointestinal Neoplasms Tumor marker Aged 80 and over chemistry.chemical_classification Macrophages Serum neopterin Tryptophan Cancer cachexia Immunosuppression General Medicine Middle Aged Biopterin Tryptophan Oxygenase Carcinoembryonic Antigen Neoplasm Proteins Enzyme Endocrinology chemistry Female |
| Zdroj: | Immunological Investigations. 24:467-478 |
| ISSN: | 1532-4311 0882-0139 |
| DOI: | 10.3109/08820139509066843 |
| Popis: | We investigated serum tryptophan (Trp), neopterin (NPT) and immunosuppressive acidic protein (IAP), one of tumor-associated tumor marker, concentrations in 28 patients with gastrointestinal tumors representing cancer cachexia and 10 healthy controls. NPT comes from activated macrophages presumably activated by tumor-sensitized T cells via gamma-interferon (IFN-gamma) excitation of the macrophages. We found that the NPT level was significantly higher than the control value. The negative correlation of NPT and Trp concentrations indicates activity of indoleamine 2,3-dioxygenase (IDO), a Trp degradating enzyme, in cancer-burden patients. The activity of IDO can be induced by cytokines such as IFN-gamma, and therefore low Trp levels may result from endogenous IFN-gamma production due to immune activation against tumors. We also found a positive correlation between NPT and IAP levels, suggesting that host immune activation against tumors played a role in the immunosuppression of cancer-burden states, followed by cancer-cachexia. |
| Databáze: | OpenAIRE |
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