New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888
| Autor: | Alexis Valentin, Luke Mani, Cécile Debitus, Joëlle Dubois, Eric Folcher, John N. A. Hooper, Beatrice Mourkazel, Valérie Jullian, William G.L. Aalbersberg, Dirk Erpenbeck, Thierry Cresteil |
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| Přispěvatelé: | Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Suberea ianthelliformis
Stereochemistry Molecular Sequence Data Plasmodium falciparum Bioengineering 01 natural sciences Biochemistry Antimalarials 03 medical and health sciences Animals Humans Organic chemistry Malaria Falciparum Tyrosine Molecular Biology 030304 developmental biology Chemical content 0303 health sciences Base Sequence biology 010405 organic chemistry Chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry General Chemistry General Medicine biology.organism_classification Porifera 0104 chemical sciences 3. Good health Molecular Medicine |
| Zdroj: | Chemistry and Biodiversity Chemistry and Biodiversity, Wiley, 2012, 9 (8), pp.1436-51. ⟨10.1002/cbdv.201100309⟩ |
| ISSN: | 1612-1872 1612-1880 |
| DOI: | 10.1002/cbdv.201100309⟩ |
| Popis: | International audience; Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine-derived compounds. Two of the new compounds were identified as araplysillin N20-formamide and its N-oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine-resistant and -sensitive strains of Plasmodium falciparum, and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny. |
| Databáze: | OpenAIRE |
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