Bicyclo[1.1.1]pentane Embedded in Porphyrinoids**

Autor: Nitika Grover, Maxime Cheveau, Brendan Twamley, Christopher J. Kingsbury, Cornelia M. Mattern, Mathias O. Senge
Rok vydání: 2023
Předmět:
Zdroj: Angewandte Chemie.
ISSN: 1521-3757
0044-8249
DOI: 10.1002/ange.202302771
Popis: We report a two-step approach to obtain synthetically versatile bicyclo[1.1.1]pentane (BCP) derivatives using Grignard reagents. This method allows the incorporation of BCP units in tetrapyrrolic macrocycles and the synthesis of a new class of calix[4]pyrrole analogues by replacing two bridging methylene groups with two BCP units. In addition, a doubly N-confused system was also formed in the presence of electron-withdrawing substituents at the BCP bridgeheads. The pyrrole rings in BCP containing macrocycles exist in 1,3-alternate or conformation, as observed from single-crystal X-ray diffraction analyses and 2D NMR spectroscopy.
Databáze: OpenAIRE
Externí odkaz: