DIVE/DPV registries: benefits and risks of analog insulin use in individuals 75 years and older with type 2 diabetes mellitus
| Autor: | Stefanie Lanzinger, Reinhard Welp, Sascha R. Tittel, Dieter Erath, Gesine van Mark, Jörg Gloyer, Peter Bramlage, Stefan Sziegoleit, Peter M. Jehle, Ralf Barion |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Diabetic ketoacidosis Endocrinology Diabetes and Metabolism medicine.medical_treatment Insulin Glargine Type 2 diabetes Hypoglycemia Risk Assessment elderly Diseases of the endocrine glands. Clinical endocrinology insulin analogs Internal medicine Diabetes mellitus medicine Humans Hypoglycemic Agents Registries Aged Aged 80 and over business.industry Insulin Type 2 Diabetes Mellitus medicine.disease RC648-665 Diabetes Mellitus Type 1 hypoglycemia Diabetes Mellitus Type 2 Female Clinical care/Education/Nutrition type 2 diabetes business Body mass index Dyslipidemia |
| Zdroj: | BMJ Open Diabetes Research & Care BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021) |
| ISSN: | 2052-4897 |
| Popis: | IntroductionThe aims of this study were to characterize insulin-treated individuals aged ≥75 years with type 2 diabetes using basal insulin analogs (BIA) or regular insulins (human insulin (HI)/neutral protamine Hagedorn (NPH)) and to compare the benefits and risks.Research design and methodsThe analysis was based on data from the DPV (Diabetes-Patienten-Verlaufsdokumentation) and DIVE (DIabetes Versorgungs-Evaluation) registries. To balance for confounders, propensity score matching for age, sex, diabetes duration, body mass index and hemoglobin A1c (HbA1c) as covariates was performed.ResultsAmong 167 300 patients aged ≥75 years with type 2 diabetes (mean age, 80.3 years), 9601 subjects used insulin regimens with basal insulin (HI/NPH or BIA). Of these 8022 propensity score-matched subjects were identified. The mean diabetes duration was ~12 years and half of the patients were male. At the time of switch, patients provided with BIA experienced more dyslipidemia (89.3% vs 85.9%; p=0.002) and took a greater number of medications (4.3 vs 3.7; pConclusionBIA were used in more individually and patient-centered therapy regimens compared with HI/NPH in patients with a mean age of 80 years. Both groups were slightly overtreated with mean HbA1c |
| Databáze: | OpenAIRE |
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