In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
| Autor: | Michiel Heron, Robert-Jan Lebbink, Stefan Nierkens, Tessa Reinders, Anniek A N Tanja, Patrique Praest, Yvonne M G van Os, Jori Symons, Rob Schuurman, L. Marije Hofstra, Dorien de Jong, Jeffrey M. Beekman, Lidewij W Rümke, Steven F. T. Thijsen, Monique Nijhuis, Femke C Groenveld, Annemarie M. J. Wensing |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
SARS-CoV-2 business.industry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 immunity AcademicSubjects/MED00290 Infectious Diseases Oncology Family medicine Health care medicine postvaccination infection Brief Reports Center (algebra and category theory) vaccine breakthrough business |
| Zdroj: | Open Forum Infectious Diseases |
| ISSN: | 2328-8957 |
| DOI: | 10.1093/ofid/ofab553 |
| Popis: | Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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