Iatrogenic benign lymphoplasia induced by allergic contact dermatitis from squaric acid dibutylester: immunohistologic study of cellular infiltrates
| Autor: | Keiko Kurata, Chidori Asagami, Marie Ogasawara, Kazue Nishioka |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Pathology T-Lymphocytes Iatrogenic Disease Dermatology Dermis Cell Movement Biopsy medicine Immunology and Allergy Humans Allergic contact dermatitis B-Lymphocytes medicine.diagnostic_test business.industry Alopecia Allergens Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Alopecia universalis Dermatitis Allergic Contact Drug Eruptions business Contact dermatitis Infiltration (medical) Cell Division Cyclobutanes Spongiosis Subcutaneous tissue |
| Zdroj: | Contact dermatitis. 28(1) |
| ISSN: | 0105-1873 |
| Popis: | We report of a 62-year-old male patient with a dull red itchy nodule on the induction area of allergic contact dermatitis to squaric acid dibutylester, which had been used for the therapy of alopecia universalis. The excised biopsy specimen showed dense infiltration of lymphoid cells in the dermis and subcutaneous tissue, associated with the formation of lymphoid follicles. Immunohistologic analysis of the infiltrates indicated mixed proliferation of T- and B-cells. A biopsy specimen from the challenge area showed spongiosis in the epidermis and lymphoid cell infiltration in the upper dermis, while the infiltrates consisted mainly of T-cells. The following points are discussed: (i) the lesion had an iatrogenic origin and the causative agent was quite evident; (ii) the route of allergen application was only through the epidermis and not directly in the dermis; (iii) lymphoid cell infiltrates of the induction and challenge areas were different. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text