Human cytomegalovirus induces a distinct innate immune response in the maternal–fetal interface
| Autor: | Dana G. Wolf, Simcha Yagel, Zichria Zakay-Rones, Debra Goldman-Wohl, Ronit Haimov-Kochman, Karen Meir, Esther Oiknine-Djian, Alon Vitenshtein, Rachel Yamin, Yiska Weisblum, Tal Imbar, Ofer Mandelboim, Hagai Amsalem, Amos Panet |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Innate immune response
Human cytomegalovirus Maternal–fetal interface Chemokine medicine.medical_treatment Placenta Congenital cytomegalovirus infection Cytomegalovirus Gene Expression Antibodies Viral 03 medical and health sciences 0302 clinical medicine Placental infection Interferon Pregnancy Virology medicine Decidua Humans Congenital viral infection 030304 developmental biology 0303 health sciences Innate immune system biology Heparin Virion biochemical phenomena metabolism and nutrition medicine.disease Antibodies Neutralizing Immunity Innate 3. Good health medicine.anatomical_structure Cytokine Immunology Cytomegalovirus Infections Host-Pathogen Interactions biology.protein Cytokines Female Inflammation Mediators Ex vivo 030215 immunology medicine.drug |
| Zdroj: | Virology. 485:289-296 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2015.06.023 |
| Popis: | The initial interplay between human cytomegalovirus (HCMV) and innate tissue response in the human maternal–fetal interface, though crucial for determining the outcome of congenital HCMV infection, has remained unknown. We studied the innate response to HCMV within the milieu of the human decidua, the maternal aspect of the maternal–fetal interface, maintained ex vivo as an integral tissue. HCMV infection triggered a rapid and robust decidual-tissue innate immune response predominated by interferon (IFN)γ and IP-10 induction, dysregulating the decidual cytokine/chemokine environment in a distinctive fashion. The decidual-tissue response was already elicited during viral-tissue contact, and was not affected by neutralizing HCMV antibodies. Of note, IFNγ induction, reflecting immune-cell activation, was distinctive to the maternal decidua, and was not observed in concomitantly-infected placental (fetal) villi. Our studies in a clinically-relevant surrogate human model, provide a novel insight into the first-line decidual tissue response which could affect the outcome of congenital infection. |
| Databáze: | OpenAIRE |
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