Do dose–volume metrics predict pulmonary function changes in lung irradiation?
| Autor: | Mary K. Martel, G.T. Henning, Aaron M. Allen, James A. Hayman, R.K. Ten Haken |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Atelectasis Vinorelbine Pulmonary function testing Carcinoma Non-Small-Cell Lung medicine Humans Radiology Nuclear Medicine and imaging Radiometry Lung cancer Lung Aged Neoplasm Staging Pneumonitis Radiation business.industry Dose fractionation Induction chemotherapy Dose-Response Relationship Radiation Middle Aged medicine.disease Respiratory Function Tests Surgery Radiation Pneumonitis Radiation therapy Oncology Regression Analysis Female Dose Fractionation Radiation Radiotherapy Conformal Nuclear medicine business medicine.drug |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 55:921-929 |
| ISSN: | 0360-3016 |
| Popis: | Purpose: To examine the ability of standard dose–volume metrics to predict pulmonary function changes as measured by pulmonary function tests (PFTs) in a group of patients with non–small-cell lung cancer treated with nonconventional beam arrangements on a Phase I dose-escalation study. In addition, we wanted to examine the correlation between these metrics. Methods and materials: Forty-three patients received a median treatment dose of 76.9 Gy (range 63–102.9). Eight patients also received induction chemotherapy with cisplatin and vinorelbine. They all had pre- and posttreatment PFTs ≥3 months (median 6.2) after treatment. The volume of normal lung treated to >20 Gy, effective volume, and mean lung dose were calculated for both lungs for all patients. Linear regression analysis was performed to determine whether correlations existed between the metrics and changes in the PFTs. Additionally, the three metrics were compared with each other to assess the degree of intermetric correlation. Results: No correlation was found between the volume of normal lung treated to >20 Gy, effective volume, and mean lung dose and changes in the PFTs. Subgroup analyses of patients without atelectasis before irradiation, Stage I and II disease, or treatment without induction chemotherapy were also performed. Again, no correlation was found between the dose–volume metrics and the PFT changes. The intermetric correlation was good among all three dose–volume metrics. Conclusion: In this relatively small series of patients, dose–volume metrics that correlate with the risk of pneumonitis did not provide a good model to predict early changes in pulmonary function as measured with PFTs. |
| Databáze: | OpenAIRE |
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