Molecular cloning and characterization of the mouse tag7 gene encoding a novel cytokine
| Autor: | Sergei L. Kiselev, Andrei A. Kabishev, E. M. Lukanidin, Olga S. Kustikova, Egor Prokhortchouk, Georgii P. Georgiev, E. V. Korobko |
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| Rok vydání: | 1998 |
| Předmět: |
Transcription
Genetic Lymphoid Tissue Molecular Sequence Data Locus (genetics) Apoptosis Biology Molecular cloning Ligands Biochemistry SOX4 Mice Gene knockin Tumor Cells Cultured SOCS5 Animals SOCS6 Amino Acid Sequence Cloning Molecular Molecular Biology Gene Base Sequence Chromosome Mapping Promoter Cell Biology Hematopoietic Stem Cells Molecular biology Cytokines Neoplasm Transplantation |
| Zdroj: | The Journal of biological chemistry. 273(29) |
| ISSN: | 0021-9258 |
| Popis: | Cloning of the mouse tag7 gene encoding a novel cytokine is described. The Tag7 protein consists of 182 amino acids. Genomic organization of the tag7 gene and its promoter region remind those of the genes of the tumor necrosis factor locus, although the tag7 gene is not linked to this locus. The gene is located on chromosome 7 at the area that corresponds to band 7A3, which has genetic linkage with lupus-like disease in mouse models. tag7 transcription is essential for lymphoid organs. It is also detected in certain areas of lungs, brain, and intestine and in some tumors. Tag7 protein is detectable in both cell-associated and soluble forms. The soluble form of Tag7 triggers apoptosis in mouse L929 cells in vitro and does not involve NF-kappaB activation. The relationship between Tag7 and tumor necrosis factor family of ligands is discussed. |
| Databáze: | OpenAIRE |
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