Thymosin 4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma
| Autor: | Elke De Bruyne, Ine Kuipers, Hartmut Goldschmidt, Tomas Bos, Karin Vanderkerken, Bernard Klein, Eline Menu, Els Van Valckenborgh, Ben Van Camp, Dirk Hose, Jo Caers |
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| Přispěvatelé: | Laboratory of hematology and immunology, Vrije Universiteit Brussel (VUB), Department of Hematology, Université de Liège, National Center for Tumor Diseases (NCTD), Universität Heidelberg [Heidelberg], Department of Internal Medicine V, Institut de recherche en biothérapie (IRB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), the Fund for Scientific Research-Vlaanderen (FWO-Vlaanderen), the Association for International Cancer Research and by a grant from the European Commission FP6 to MSCNET. E Menu is a post-doctoral fellow of FWO-Vlaanderen., Hematology, Frei, Monique, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Down-Regulation Apoptosis Thymosin Beta 4 Biology Mice 03 medical and health sciences 0302 clinical medicine Autologous stem-cell transplantation Cell Movement Cell Line Tumor Internal medicine [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology medicine Animals Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Survival rate Multiple myeloma Cell Proliferation 030304 developmental biology cellular proliferation 0303 health sciences Hematology Tumor Suppressor Proteins the murine 5TMM model Thymosin Cancer Prognosis medicine.disease 3. Good health Gene Expression Regulation Neoplastic Mice Inbred C57BL Survival Rate multiple myeloma Thymosin beta-4 Disease Models Animal HEK293 Cells myeloma Endocrinology 030220 oncology & carcinogenesis Cancer research Brief Reports thymosin beta |
| Zdroj: | Haematologica Haematologica, Ferrata Storti Foundation, 2010, 95 (1), pp.163-7. ⟨10.3324/haematol.2009.006411⟩ |
| ISSN: | 1592-8721 0390-6078 |
| DOI: | 10.3324/haematol.2009.006411 |
| Popis: | International audience; Thymosin beta4 (Tbeta4) is a polypeptide involved in cellular proliferation, differentiation, and migration, over-expressed in several tumor entities. We evaluated its expression and function in 298 newly diagnosed multiple myeloma patients and the murine 5TMM model. Mean Tbeta4 expression was significantly lower in myeloma cells compared to normal plasma cells (P |
| Databáze: | OpenAIRE |
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