Central hypotensive action of bridge analogues of clonidine
| Autor: | P. A. Van Zwieten, Pieter B.M.W.M. Timmermans, J.C.J. Mackaay, P.H.M. Fluitman |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Central Nervous System
Male medicine.medical_specialty Time Factors Central nervous system Anaesthetized cats Pharmacology Hypotensive Drugs Hypotensive action Clonidine Heart Rate Internal medicine medicine Animals Antihypertensive Agents Dose-Response Relationship Drug Chemistry Hemodynamics General Medicine medicine.anatomical_structure Bridge (graph theory) Endocrinology Mechanism of action Nitrogen atom Cats Female medicine.symptom medicine.drug |
| Zdroj: | Pharmacology. 19(6) |
| ISSN: | 0031-7012 |
| Popis: | The experimental compounds St-1913, St-1966 and St-1967 in which the bridging nitrogen atom, as found in clonidine, has been replaced by a methylene (--CH2--) function, an oxygen or a sulphur atom, respectively, have been investigated with respect to their acute hypotensive effects in anaesthetized cats. Attention was paid to a possible contribution of the central nervous system to the hypotensive action of the drugs by means of vertebral arterial infusions. Although less active than clonidine, St-1913 and St-1967 are centrally acting hypotensive drugs. Central alpha-adrenoceptors are presumably involved in a similar manner as in the mechanism of clonidine. The hypotensive potency of St-1966 was much lower compared to the aforementioned drugs. A central origin for its depressor effects could be established. However, central alpha-adrenoceptors probably do not participate. In spite of its structural similarity with clonidine the mechanism of action of St-1966 appears to be different. |
| Databáze: | OpenAIRE |
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