Morphologic Changes in the Inner Ear of Chinchilla Laniger after Middle Ear Administration of Gentamicin in a Sustained‐Release Vehicle
| Autor: | Michael J. O'Leary, Michael J. DeCicco, Richard D. Kopke, Michael E. Hoffer, Jenifer Henderson, Ben J. Balough, Carey D. Balaban, Derin Wester |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Chinchilla Empirical data Pathology medicine.medical_specialty Time Factors Drug Evaluation Preclinical Fibrin 03 medical and health sciences 0302 clinical medicine Animal model biology.animal Hair Cells Auditory medicine Animals Inner ear 030223 otorhinolaryngology Heat-Shock Proteins Meniere Disease biology business.industry Immunohistochemistry Anti-Bacterial Agents Disease Models Animal Instillation Drug medicine.anatomical_structure Otorhinolaryngology Delayed-Action Preparations Ear Inner 030220 oncology & carcinogenesis Middle ear biology.protein Female Surgery Gentamicin sense organs Hair cell Gentamicins business medicine.drug |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 120:643-648 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1053/hn.1999.v120.a91762 |
| Popis: | The use of transtympanic gentamicin has become a popular method of treating Meniere's disease; nevertheless, many questions still remain regarding this therapy. Until investigators can control the exact amount of medicine that is administered to the ear and have an understanding of the kinetics of gentamicin, therapy will continue to rely on empirical data. Previously we described the use of a fibrin-based sustained-release vehicle impregnated with gentamicin in the middle ears of chinchillas. With this model a kinetics curve of gentamicin was defined. The inner ears of these animals were submitted for immunohistochemical and histologic analysis. We discuss the ultrastructural changes seen and correlate this to our kinetics data. We also examine measurement of hair cell damage with heat shock protein levels. By better understanding the actions of gentamicin in this animal model, we hope to facilitate safer use of intratympanic medicines in our patient population. |
| Databáze: | OpenAIRE |
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