The effect of acute administration of chlorothiazide upon the pressor responsiveness to angiotensin and norepinephrine
| Autor: | R. Ellwood Jones, F.A. Bashour, Norman M Kaplan, Jack G. Silah |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
medicine.medical_specialty
Angiotensins Baroreceptor Blood Pressure Pressoreceptors Norepinephrine (medication) Norepinephrine Internal medicine Renin–angiotensin system medicine Humans Pharmacology business.industry Blood Pressure Determination Blood flow Chlorothiazide Hydrogen-Ion Concentration Angiotensin II Endocrinology Blood pressure Pressor response Cardiology and Cardiovascular Medicine business Blood Flow Velocity circulatory and respiratory physiology medicine.drug |
| Zdroj: | American Heart Journal. 69:301-305 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/0002-8703(65)90269-3 |
| Popis: | The effects of the acute intravenous administration of chlorothiazide upon the pressor responsiveness to norepinephrine and angiotensin II in normal human subjects have been examined by measuring blood pressure and digital blood flow. Chlorothiazide did blunt the pressor responsiveness to norepinephrine, but not to angiotensin, when they were administered in the same infusion. Chlorothiazide did not decrease pressor responsiveness to either agent when they were administered simultaneously but in separate infusions. The effect of chlorothiazide upon the pressor response to norepinephrine when the two are admixed is presumably related to instability of norepinephrine in the alkaline pH of the chlorothiazide solution. |
| Databáze: | OpenAIRE |
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