Improvement in the deformity of the face in Paget's disease treated with diphosphonates
| Autor: | P.H. Burke, J. A. Kanis, D.P. O'Doherty, D. L. Douglas, D. R. Bickerstaff |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Bone disease Cephalometry medicine.medical_treatment Dentistry medicine Deformity Humans Skeletal deformity Orthopedics and Sports Medicine Reduction (orthopedic surgery) Aged Aged 80 and over Chemotherapy Diphosphonates business.industry Skull Etidronic Acid Middle Aged Alkaline Phosphatase Osteitis Deformans medicine.disease Surgery Paget s disease medicine.anatomical_structure Face Photogrammetry Female Clodronic Acid medicine.symptom business |
| Zdroj: | The Journal of Bone and Joint Surgery. British volume. :132-136 |
| ISSN: | 2044-5377 0301-620X |
| DOI: | 10.1302/0301-620x.72b1.2137127 |
| Popis: | We studied nine patients with Paget's disease affecting the skull or facial bones, who were subsequently treated with either dichloromethylene diphosphonate (clodronate) or ethylene-1-hydroxy-1,1-diphosphonate (etidronate). Long-term treatment induced a clinical and biochemical improvement in eight, and this was associated with a reduction in maxillary or skull volume as assessed by quantitative stereophotogrammetry. The one patient whose disease was resistant to treatment with diphosphonate, showed no change in maxillary shape. These studies suggest that the long-term control of disease activity attained with diphosphonates, results in the improvement of skeletal deformity. |
| Databáze: | OpenAIRE |
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