Evaluation of salidrosidein vitroandin vivogenotoxicity
| Autor: | Yiwen Zheng, Jiangbo Zhu, Yuping Zhu, Tianbao Zhang, Xili Ma, Xuying Wan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Salmonella typhimurium Health Toxicology and Mutagenesis CHO Cells Pharmacology Toxicology medicine.disease_cause Antiviral Agents Virus Mice chemistry.chemical_compound Cricetulus Glucosides Phenols In vivo Cricetinae medicine Animals Medicine Chinese Traditional Micronuclei Chromosome-Defective Micronucleus Tests Chemical Health and Safety biology Salidroside Public Health Environmental and Occupational Health General Medicine biology.organism_classification In vitro Rhodiola rosea chemistry Mutagenesis Toxicity Micronucleus test Microsomes Liver Female Rhodiola Genotoxicity Mutagens |
| Zdroj: | Drug and Chemical Toxicology. 33:220-226 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.3109/01480540903373654 |
| Popis: | It is reported that salidroside, the main component of a traditional Chinese medicine, Rhodiola rosea, has the efficacy of protecting Coxsackie virus impairment. As part of a safety evaluation on salidroside for use in the treatment of viral myocarditis, the present study evaluated potential genotoxicity of salidroside by using the standard battery of tests (i.e., bacterial reverse mutation assay, chromosomal aberrations assay, and mouse micronucleus assay) recommended by the State Food and Drug Administration of China. The results showed that salidroside was not genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay, and mouse micronucleus assay conditions. The anticipated clinical dose seems to be smaller than the doses administered in the genotoxicity assays. With confirmation from further toxicity studies, salidroside would hopefully prove to be a safe anti-Coxsackie virus agent. |
| Databáze: | OpenAIRE |
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