The development of 11C-carbonylation chemistry : A systematic view
| Autor: | Gunnar Antoni, Bengt Långström, O. Itsenko, Jonas Eriksson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Positron emission tomography Organisk kemi Simplified methods Synthesis methods Organic Chemistry Nanotechnology Carbon-11 030218 nuclear medicine & medical imaging C-11-carbonylation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine PET chemistry 030220 oncology & carcinogenesis Molecular Medicine Radiology Nuclear Medicine and imaging Phosgene Carbon monoxide Carbonylation |
| Popis: | The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including C-11-carbonylations and refined techniques to handle [C-11]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [C-11]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [C-11]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [C-11]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [C-11]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the C-11-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of C-11-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for C-11-carbonylations. But as this review shows, novel and greatly simplified methods to handle [C-11]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement C-11-carbonylation protocols will increase. |
| Databáze: | OpenAIRE |
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