Posterior reversible encephalopathy in a GT1a positive oculopharyngeal variant of Guillain-Barré syndrome: A case-report and review of the literature
| Autor: | Antonios Provatas, Katerina Markou, Efthimios Dardiotis, Styliani Ralli, Georgia Xiromerisiou, Dimitrios Rikos, Zisis Tsouris, Stefania Kalampokini |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Encephalopathy Context (language use) Neurological disorder Primary Dysautonomias Guillain-Barre Syndrome 03 medical and health sciences 0302 clinical medicine Gangliosides medicine Humans Adult patients Guillain-Barre syndrome business.industry Incidence (epidemiology) Dysautonomia Immunoglobulins Intravenous Posterior reversible encephalopathy syndrome General Medicine medicine.disease 030220 oncology & carcinogenesis Surgery Female Neurology (clinical) Posterior Leukoencephalopathy Syndrome medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Clinical neurology and neurosurgery. 196 |
| ISSN: | 1872-6968 |
| Popis: | Guillain-Barre syndrome (GBS) is the most common cause of acute flaccid paralysis and its incidence increases with age, although all age groups can be affected. The cranial subtypes of GBS account for approximately 5% of cases. Posterior reversible encephalopathy syndrome (PRES) is an acute neurological disorder, mostly reversible but with increased morbidity with permanent neurological sequelae in severe cases. The coexistence of these two syndromes is very rare and underdiagnosed. To the best of our knowledge, there are several dozen cases reported in the literature including ours with the coexistence of these two syndromes in adult patients. We present a rare case of oculopharyngeal type of GBS followed by PRES syndrome. Based on the reviewed cases we discuss various pathogenic mechanisms that support the association between these two entities. This review illustrates the importance of detecting PRES syndrome in the context of acute inflammatory immune-mediated polyneuropathies especially when the patients present early dysautonomia. We also discuss the importance of early administration of immunoglobulin (IVIG) treatment but the possible risks that poses to the occurrence of PRES syndrome as well. |
| Databáze: | OpenAIRE |
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