H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
| Autor: | Amir El Rahal, Alejandro Bustamante, Jean-Charles Sanchez, Asita Sarrafzadeh, Manuel Quintana, Carmen Melinda Prica, Andereggen E, Roser García-Armengol, Juan José Egea-Guerrero, Linnéa Lagerstedt, Natacha Turck, Ana Rodríguez-Rodríguez, Joan Montaner, Karl Lothard Schaller, Lara Rinaldi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Time Factors Critical Care and Emergency Medicine Traumatic Brain Injury lcsh:Medicine Pathology and Laboratory Medicine Biochemistry Vascular Medicine Diagnostic Radiology 0302 clinical medicine Patient Admission Medicine and Health Sciences Brain Damage lcsh:Science Stroke Tomography Trauma Medicine Aged 80 and over Multidisciplinary Radiology and Imaging Heart Middle Aged Neurology Biomarker (medicine) Female medicine.symptom Anatomy Fatty Acid Binding Protein 3 Traumatic Injury Research Article Adult medicine.medical_specialty Traumatic brain injury Imaging Techniques Hemorrhage Neuroimaging Brain damage S100 Calcium Binding Protein beta Subunit Fatty Acid-Binding Proteins Research and Analysis Methods Sensitivity and Specificity 03 medical and health sciences Text mining Signs and Symptoms Diagnostic Medicine Internal medicine medicine Humans Glasgow Coma Scale ddc:576 Brain Concussion Aged ddc:613 business.industry lcsh:R Biology and Life Sciences 030208 emergency & critical care medicine medicine.disease Computed Axial Tomography ddc:616.8 Institutional repository Cardiovascular Anatomy Lesions lcsh:Q business Tomography X-Ray Computed Neurotrauma 030217 neurology & neurosurgery Biomarkers Neuroscience |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname PLoS ONE, Vol 12, Iss 4, p e0175572 (2017) PLOS ONE, Vol. 12, No 4 (2017) P. e0175572 PLoS ONE Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| ISSN: | 1932-6203 |
| Popis: | The majority of patients with mild traumatic brain injury (mTBI) will have normal Glasgow coma scale (GCS) of 15. Furthermore, only 5%–8% of them will be CT-positive for an mTBI. Having a useful biomarker would help clinicians evaluate a patient’s risk of developing intracranial lesions. The S100B protein is currently the most studied and promising biomarker for this purpose. Heart fatty-acid binding protein (H-FABP) has been highlighted in brain injury models and investigated as a biomarker for stroke and severe TBI, for example. Here, we evaluate the performances of S100B and H-FABP for differentiating between CT-positive and CT-negative patients. A total of 261 patients with a GCS score of 15 and at least one clinical symptom of mTBI were recruited at three different European sites. Blood samples from 172 of them were collected ≤ 6 h after trauma. Patients underwent a CT scan and were dichotomised into CT-positive and CT-negative groups for statistical analyses. H-FABP and S100B levels were measured using commercial kits, and their capacities to detect all CT-positive scans were evaluated, with sensitivity set to 100%. For patients recruited ≤ 6 h after trauma, the CT-positive group demonstrated significantly higher levels of both H-FABP (p = 0.004) and S100B (p = 0.003) than the CT-negative group. At 100% sensitivity, specificity reached 6% (95% CI 2.8–10.7) for S100B and 29% (95% CI 21.4–37.1) for H-FABP. Similar results were obtained when including all the patients recruited, i.e. hospital arrival within 24 h of trauma onset. H-FABP out-performed S100B and thus seems to be an interesting protein for detecting all CT-positive mTBI patients with a GCS score of 15 and at least one clinical symptom. |
| Databáze: | OpenAIRE |
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