Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling Peptides
| Autor: | Paula T. Hammond, Bryan B. Hsu, Manav Mehta, Cory M. Tschabrunn, Monica B. Perez-Cuevas, Shuguang Zhang, William Conway |
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| Rok vydání: | 2015 |
| Předmět: |
food.ingredient
Materials science Swine Nanofibers General Physics and Astronomy Hemorrhage Nanotechnology Gelatin Article Hemostatics Fibrin food Self assembling Animals General Materials Science Porcine skin Blood Coagulation Wound Healing biology Wound Closure Techniques General Engineering blood clots bleeding 16. Peace & justice Bandages Disease Models Animal Nanofiber Hemostasis biology.protein Peptides Wound healing wound dressings Biomedical engineering |
| Zdroj: | ACS Nano |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | Uncontrolled bleeding from traumatic wounds is a major factor in deaths resulting from military conflict, accidents, disasters and crime. Self-assembling peptide nanofibers have shown superior hemostatic activity, and herein, we elucidate their mechanism by visualizing the formation of nanofiber-based clots that aggregate blood components with a similar morphology to fibrin-based clots. Furthermore, to enhance its direct application to a wound, we developed layer-by-layer assembled thin film coatings onto common materials used for wound dressings-gauze and gelatin sponges. We find these nanofibers elute upon hydration under physiological conditions and generate nanofiber-based clots with blood. After exposure to a range of harsh temperature conditions (-80 to 60 °C) for a week and even 5 months at 60 °C, these hemostatic bandages remain capable of releasing active nanofibers. In addition, the application of these nanofiber-based films from gauze bandages was found to accelerate hemostasis in porcine skin wounds as compared to plain gauze. The thermal robustness, in combination with the self-assembling peptide's potent hemostatic activity, biocompatibility, biodegradability, and low cost of production, makes this a promising approach for a cheap yet effective hemostatic bandage. |
| Databáze: | OpenAIRE |
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