Interleukin-18 (IL-18) Cytokine Serum Concentrations Correlate With Pain Scores and the Number of Analgesic Doses Following Surgery

Autor:	Maaret, Eskelinen, Iina, Saimanen, Tuomas, Selander, Anu, Holopainen, Samuli, Aspinen, Esa, Hämäläinen, Matti, Eskelinen
Rok vydání:	2022
Předmět:	Analgesics Pain Postoperative Cancer Research Interleukin-6 Interleukins Interleukin-8 Interleukin-18 Pain General Medicine NAD Interleukin-10 Interleukin 1 Receptor Antagonist Protein C-Reactive Protein Oncology Humans Cytokines
Zdroj:	Anticancer Research. 42:5521-5526
ISSN:	1791-7530 0250-7005
DOI:	10.21873/anticanres.16057
Popis:	Anti- and proinflammatory cytokines and plasma high-sensitivity C-reactive protein (hs-CRP) are used to assess inflammatory stress response (ISR) following surgery. However, the serum IL-18 (interleukin-18) cytokine values versus numeric rating scale (NRS) pain score and number of analgesic doses (NAD) postoperatively are unknown.Blood levels of six interleukins (IL-18, IL-1ra, IL-6, IL-10, IL-1β, and IL-8) and hs-CRP were measured at three time points; before operation (PRE), immediately after operation (POP1), and six hours after operation (POP2) in 114 patients with cholelithiasis.Following surgery, the blood levels of hs-CRP and IL-1ra, IL-6, IL-10, and IL-1β cytokines had a trend for increase (p0.001 and p=0.014, respectively). The serum IL-18 concentrations inversely correlated to NRS and NAD during the first 24 h postoperatively.The correlation of IL-18 levels to NRS and NAD values supports the hypothesis that ISR and pain are related.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3112de5d105ae2704b797cc20d99c88f https://doi.org/10.21873/anticanres.16057 Zobrazit plný text záznamu