Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors
| Autor: | Iohanna Deckmann, Carmem Gottfried, Victorio Bambini-Junior, Gustavo Brum Schwingel, Mellanie Fontes-Dutra, Júlio Santos-Terra |
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| Rok vydání: | 2021 |
| Předmět: |
Nervous system
medicine.medical_specialty Mental Disorders Context (language use) Biology medicine.anatomical_structure Developmental Neuroscience Environmental risk C848 Transcription (biology) Neurodevelopmental Disorders Risk Factors Gene expression medicine Animals Humans Gene-Environment Interaction Convergence (relationship) Psychiatry Transcription factor Developmental Biology Immune activation Transcription Factors |
| Zdroj: | International journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceREFERENCES. 81(7) |
| ISSN: | 1873-474X 0736-5748 |
| Popis: | Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of psychiatric conditions marked by impairments in the nervous system. Their onset occurs during gestation, and the alterations are observed throughout the postnatal life. Although many genetic and environmental risk factors have been described in this context, the interactions between them challenge the understanding of the pathways associated with NDDs. Transcription factors (TFs) - a group of over 1,600 proteins that can interact with DNA, regulating gene expression through modulation of RNA synthesis, represent a point of convergence for different risk factors. In addition, TFs organize critical processes like angiogenesis, blood-brain barrier formation, myelination, neuronal migration, immune activation, and many others in a time and location-dependent way. In this review, we summarize important TF alterations in NDD and associated disorders, along with specific impairments observed in animal models, and, finally, establish hypotheses to explain how these proteins may be critical mediators in the context of genome-environment interactions. |
| Databáze: | OpenAIRE |
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