Effects of Benidipine Hydrochloride on Autonomic Nervous Activity in Hypertensive Patients with Highand Low-salt Diets
| Autor: | Tomohito Kawano, Hiroshi Okamoto, Toru Nakayama, Norihito Kageyama, Ken Saito, Kansei Katoh, Akiyoshi Nishikado, Susumu Ito, Kanji Kusunoki, Eiko Uemura, Yuko Sawa, Masahiro Nomura, Akiko Iga, Yutaka Nakaya |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Dihydropyridines medicine.medical_specialty Sodium chemistry.chemical_element Hemodynamics Blood Pressure Autonomic Nervous System Excretion chemistry.chemical_compound Heart Rate Internal medicine Drug Discovery Heart rate medicine Humans Circadian rhythm Aged Chemistry Sodium Dietary BENIDIPINE HYDROCHLORIDE Diet Sodium-Restricted Middle Aged Calcium Channel Blockers Circadian Rhythm Blood pressure Endocrinology Hypertension Benidipine Female |
| Zdroj: | Arzneimittelforschung. 53:314-320 |
| ISSN: | 1616-7066 0004-4172 |
| DOI: | 10.1055/s-0031-1297115 |
| Popis: | The effects of benidipine hydrochloride (CAS 91559-74-5, Coniel) on autonomic nervous activity in hypertensive patients with high- and low-salt diets were investigated. Six patients having a urinary sodium excretion of 80 mEq/day or less (low salt group) and 6 patients having a urinary sodium excretion of 200 mEq/day or more (high salt group) were orally given benidipine hydrochloride (4 mg). Before and four weeks after the treatment with benidipine, 24-h circadian variation in blood pressure and 24-h Holter electrocardiogram (ECG) were recorded. The low frequency power spectrum of heart rate (LF power; 0.04-0.15 Hz), high frequency power spectrum of heart rate (HF power; 0.15-0.40 Hz), and the ratio of LF to HF (LF/HF) were calculated, and these parameters were averaged every hour in every subject. HF power was significantly lower and LF/HF ratio was significantly higher in the high-salt group than in the low-salt group before the treatment. However, the benidipine treatment significantly increased the HF power in both groups, particularly in the high-salt group, and significantly decreased the LF/HF ratio in both groups. Moreover, there was no significant difference in the antihypertensive effect of benidipine between the high- and low-salt intake groups. These results suggest that benidipine favourably influences blood pressure and autonomic nervous activity in hypertensive patients with a high-salt intake. It is concluded that benidipine may be useful for improving the development of salt-induced hypertension and its accompanying haemodynamic responses. |
| Databáze: | OpenAIRE |
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