PULSATILE SUBCUTANEOUS NOCTURNAL ADMINISTRATION OF GnRH BY PORTABLE INFUSION PUMP IN HYPOGONADOTROPIC HYPOGONADISM: INITIATION OF GONADOTROPIN RESPONSIVENESS
| Autor: | RONALD I. JACOBSON, EVERETT L. SEYLER, WILLIAM V. TAMBORLANE, JOSEPH M. GERTNER, MYRON GENEL |
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| Rok vydání: | 1979 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Adolescent Kallmann syndrome medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Pulsatile flow Gonadotropin-releasing hormone Biochemistry Gonadotropin-Releasing Hormone Endocrinology Hypogonadotropic hypogonadism Infusion Procedure Internal medicine medicine Humans Infusion pump Testosterone business.industry Hypogonadism Biochemistry (medical) Luteinizing Hormone medicine.disease Kinetics Follicle Stimulating Hormone Gonadotropin business hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 49:652-654 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-49-4-652 |
| Popis: | GnRH was administered subcutaneously in hourly pulses for 10 consecutive nights to two immature males with Kallmann's Syndrome using a portable, battery-operated infusion pump adapted for home use. Pulsatile GnRH produced a progressive increase in urinary gonadotropin excretion, a significant increase in mean basal plasma FSH, pulsatile LH release, and an increased LH response to a standard 3 hour GnRH infusion test. One subject developed a striking increment in plasma testosterone in response to GnRH pulses, as well as a biphasic LH response to the 3 hour infusion. |
| Databáze: | OpenAIRE |
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