Macrolide antibiotics protect neurons in culture against theN-methyl-d-aspartate (NMDA) receptor-mediated toxicity of glutamate
| Autor: | Daria Milani, M. Favaron, Maria Lipartiti, Emanuela Fadda, Hari Manev, Paolo Candeo |
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| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Excitotoxicity Glutamic Acid chemistry.chemical_element Pharmacology Biology Calcium medicine.disease_cause Receptors N-Methyl-D-Aspartate Tacrolimus Macrolide Antibiotics Glutamates Immunophilins Cerebellum Internal medicine medicine Animals Molecular Biology Cells Cultured Neurons Dose-Response Relationship Drug General Neuroscience Glutamate receptor Anti-Bacterial Agents medicine.anatomical_structure Endocrinology nervous system chemistry Cell culture NMDA receptor Neurology (clinical) Neuron Granulocytes Developmental Biology |
| Zdroj: | Brain Research. 624:331-335 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(93)90098-8 |
| Popis: | The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in culture against NMDA- but not kainate-mediated excitotoxicity. The effect was structure-dependent: larger macrolide rings were more active. Macrolides did not affect the 3-(2-carboxypiperazin-4yl)-propyl-1-phosphonic acid (CPP) binding or the NMDA-mediated calcium influx. |
| Databáze: | OpenAIRE |
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