Regulation of Insulin and Insulin-Like Activity in Malnourished Patients with Carcinoma Ventriculi Subjected to Total Gastrectomy and Personalized Nutritional Support/ Kontrola insulinske i aktivnosti slične insulinu kod neuhranjenih pacijenata sa tumorom želuca podvrgnutih totalnoj gastrektomiji i lično adaptiranoj ishrani
| Autor: | Goran Miljuš, Olgica N. Nedić, Vesna Malenković |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
insulin medicine.medical_treatment interleukin 6 030209 endocrinology & metabolism Insulin-like growth factor-binding protein lcsh:Biochemistry 03 medical and health sciences 0302 clinical medicine faktor rasta sličan insulinu I Internal medicine Medicine enteral nutrition lcsh:QD415-436 030212 general & internal medicine Interleukin 6 Carcinoma ventriculi insulin-like growth factor binding proteins totalna gastrektomija 2. Zero hunger biology enteralna ishrana business.industry Insulin Interleukin total gastrectomy insulin-like growth factor I vezujući proteini za faktore rasta slične insulinu Parenteral nutrition Endocrinology Basal (medicine) biology.protein Gastrectomy business |
| Zdroj: | Journal of Medical Biochemistry, Vol 35, Iss 1, Pp 17-25 (2016) |
| ISSN: | 1452-8266 |
| Popis: | SummaryBackground: Insulin and insulin-like growth factor (IGF) activities are disturbed during critical illness. Time-course changes in the concentrations of insulin, IGF-I and IGFbinding proteins (IGFBPs) were monitored in this study and their correlation with interleukin (IL)-6 was assessed in patients subjected to total gastrectomy and specific nutritional regime.Methods: Patients were fed post-operatively according to the following scheme: parenteral nutrition on day 1, enteral nutrition combined with parenteral form from day 2 to 7, peroral nutrition from day 8 and full oral nutrition from day 14. Blood samples were taken periodically and the levels of IL-6, insulin, IGF-I and IGFBP-1 to -4 were determined.Results: On day 1 post-operatively, the concentration of IL- 6 reached its maximum and decreased afterwards. The concentration of insulin increased until day 3 and then started to fall. The concentration of IGF-I, already low preoperatively, continued to decrease. The concentration of IGFBP-1 peaked on day 1 post-operatively, whereas the concentration of IGFBP-3 decreased on that day. The concentration of IL-6 correlated positively with the concentration of IGFBP-1 and negatively with IGFBP-3. On day 14, the concentrations of IL-6, insulin and IGFBP-1 returned to or were close to their basal levels, whereas the concentrations of IGF-I and IGFBP-3 remained reduced.Conclusions: 14-day post-operative recovery, which included specific nutritional support, was suitable to restore insulin concentration and re-establish IGFBP-1 regulation primarily by nutrition. Very low IGF-I level on day 14 after surgery and IGFBP-3 concentration still lower than before surgery indicated that the catabolic condition was not compensated. |
| Databáze: | OpenAIRE |
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