Risk of Venous Thromboembolism in Acute Necrotizing Pancreatitis
| Autor: | Muhammad S. Panhwar, Emad Mansoor, Mariam N. Rana, Zachary L. Smith, Dina Ahmad, Muhammed Mustafa Alikhan, Richard C.K. Wong |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Acute necrotizing pancreatitis medicine.medical_specialty Time Factors Multivariate analysis Adolescent Databases Factual Endocrinology Diabetes and Metabolism Comorbidity Risk Assessment Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine Internal Medicine medicine Electronic Health Records Humans cardiovascular diseases Aged Retrospective Studies Hepatology Pancreatitis Acute Necrotizing business.industry Incidence Incidence (epidemiology) Venous Thromboembolism Odds ratio Middle Aged medicine.disease United States Confidence interval Cross-Sectional Studies 030220 oncology & carcinogenesis Acute pancreatitis Pancreatitis Female 030211 gastroenterology & hepatology business Venous thromboembolism |
| Zdroj: | Pancreas. 50:71-76 |
| ISSN: | 1536-4828 0885-3177 |
| DOI: | 10.1097/mpa.0000000000001714 |
| Popis: | OBJECTIVES Studies on the incidence of venous thromboembolism (VTE) in acute pancreatitis (AP) are scarce. We conducted a large database study to evaluate this relationship. METHODS Data were extracted from a large electronic health record (Explorys; IBM Watson Health, Armonk, NY). We identified patients with AP in 2018 and 2019, analyzing VTE incidence at 30 days after diagnosis of AP. Univariate and multivariate analyses were performed to identify risk factors associated with VTE. RESULTS A total of 25,620 cases of acute necrotizing pancreatitis (ANP) and 155,800 cases of acute nonnecrotizing pancreatitis (ANNP) were identified. The incidence of VTE was 7.1% for ANP, compared with 2.8% in ANNP (P < 0.001). On multivariate analysis, ANP conferred significantly greater odds of VTE (adjusted odds ratio, 2.78; 95% confidence interval, 2.73-2.84; P < 0.001), independent of other variables. In those with ANP, the presence of VTE was associated with a significantly higher mortality (23.5% vs 15.9%, P < 0.001). CONCLUSIONS Acute necrotizing pancreatitis carries near 2.5-fold risk of VTE, and a 3-fold risk of PE, compared with those with ANNP. Venous thromboembolism development in ANP is associated with higher mortality. |
| Databáze: | OpenAIRE |
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