CYP1A1 Val 462 and NQO1 Ser 187 polymorphisms, cigarette use, and risk for colorectal adenoma
| Autor: | Sunita Yadavalli, Meredith Yeager, Richard B. Hayes, Neil E. Caporaso, Joel L. Weissfeld, Stephen J. Chanock, Andrea A. Baccarelli, Nilanjan Chatterjee, Lifang Hou, Wen Yi Huang, Bu Tian Ji, Robert S. Bresalier |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adenoma
Male Risk Cancer Research medicine.medical_specialty Colorectal cancer Rectum Colorectal adenoma Gastroenterology Tobacco smoke Descending colon Internal medicine Genotype Cytochrome P-450 CYP1A1 NAD(P)H Dehydrogenase (Quinone) medicine Humans Genetic Predisposition to Disease Allele Alleles Aged Polymorphism Genetic business.industry Smoking General Medicine Middle Aged medicine.disease medicine.anatomical_structure Endocrinology Female Colorectal Neoplasms business |
| Zdroj: | Carcinogenesis. 26:1122-1128 |
| ISSN: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/bgi054 |
| Popis: | Cigarette use is a risk factor for colorectal adenoma, a known precursor of colorectal cancer. Polymorphic variants in NQO1 and CYP1A1 influence the activation of carcinogenic substances in tobacco smoke, possibly impacting on tobacco-associated risks for colorectal tumors. We investigated the association of cigarette smoking with risk for advanced colorectal adenoma in relation to the CYP1A1 Val(462) and NQO1 Ser(187) polymorphic variants. Subjects were 725 non-Hispanic Caucasian cases with advanced colorectal adenoma of the distal colon (descending colon, sigmoid and rectum) and 729 gender- and ethnicity-matched controls, randomly selected from participants in the prostate, lung, colorectal and ovarian cancer screening trial. Subjects carrying either CYP1A1 Val(462) or NQO1 Ser(187) alleles were weakly associated with risk of colorectal adenoma; however, subjects carrying both CYP1A1 Val(462) and NQO1 Ser(187) alleles showed increased risks (OR = 2.2, 95% CI = 1.1-4.5), particularly among recent (including current) (OR = 17.4, 95% CI = 3.8-79.8, P for interaction = 0.02) and heavy cigarette smokers (>20 cigarettes/day) (OR = 21.1, 95% CI = 3.9-114.4, P for interaction = 0.03) compared with non-smokers who did not carry either of these variants. These genotypes were unassociated with risk in non-smokers. In analysis of adenoma subtypes, the combined gene variants were most strongly associated with the presence of multiple adenoma (P = 0.002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions. |
| Databáze: | OpenAIRE |
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