Increased in vitro production and serum levels of the soluble lipopolysaccharide receptor sCD14 in liver disease
| Autor: | Christian Müller, F. Pfeffel, Dagmar Petermann, Christian Oesterreicher |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Lipopolysaccharides Male medicine.medical_specialty Alcoholic liver disease Cirrhosis Lipopolysaccharide CD14 Lipopolysaccharide Receptors Enzyme-Linked Immunosorbent Assay Monocytes Liver disease chemistry.chemical_compound Internal medicine medicine Humans Hepatology business.industry Liver Diseases Monocyte Middle Aged Jaundice medicine.disease Endocrinology medicine.anatomical_structure chemistry Immunology Female Interleukin-4 medicine.symptom Viral hepatitis business |
| Zdroj: | Journal of Hepatology. 23:396-402 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/0168-8278(95)80197-9 |
| Popis: | Elevated concentrations of lipopolysaccharide have been found in serum of patients with severe parenchymal liver disease and its toxic effect is thought to involved in hemodynamic disturbances seen in cirrhosis. A soluble form of the receptor (sCD14) for lipopolysaccharide is present in serum and is released by stimulated macrophages, indicating macrophage activation. We investigated sCD14 serum levels and in vitro production by lipopolysaccharide stimulated peripheral blood monocytes in patients with various liver diseases. In acute viral hepatitis serum sCD14 levels were significantly higher during the first 2 weeks after onset of jaundice (n=11; 3.6 +/- 0.9 microg /ml (mean +/- SD)) than in healthy control individuals (n=52; 2.5 +/- 0.7 microg/ml; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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