Various Motor and Non-Motor Symptoms in Early Multiple System Atrophy
Autor: | Ji Hyun Choi, Dallah Yoo, Han Joon Kim, Beomseok Jeon, Jin Hee Im, Yu Jin Jung, Hui Jun Yang |
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Rok vydání: | 2019 |
Předmět: |
Male
Pediatrics medicine.medical_specialty Stridor REM sleep behavior disorder 050105 experimental psychology Diagnosis Differential 03 medical and health sciences Dysarthria 0302 clinical medicine Atrophy stomatognathic system mental disorders parasitic diseases medicine Humans 0501 psychology and cognitive sciences Cerebellar ataxia business.industry Parkinsonism 05 social sciences Middle Aged Multiple System Atrophy medicine.disease Dysphagia nervous system diseases Cross-Sectional Studies Sexual dysfunction nervous system Neurology Disease Progression Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
Zdroj: | Neurodegenerative Diseases. 19:238-243 |
ISSN: | 1660-2862 1660-2854 |
Popis: | Background: Multiple system atrophy (MSA) patients present a variety of symptoms other than autonomic dysfunctions, parkinsonism, and cerebellar ataxia. The aim of this study was to evaluate the frequency of various motor and non-motor symptoms including so-called “red flags” in patients with early MSA and to determine whether the frequency of these symptoms was different between the parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes. Methods: Sixty-one probable or possible MSA patients with disease duration of 3 years or less were included. Patients were classified into MSA-P, MSA-C, and MSA-PC. The frequency of 13 features including various motor and non-motor symptoms that commonly occur in MSA was assessed. Results: Dysarthria was the most prevalent feature (98.4%) followed by sexual dysfunction (95.1%). Probable REM sleep behavior disorder was present in 90.2%. The frequency of constipation (82.0%), dysphagia (68.9%), and snoring (70.5%) was also high. Stridor was present in 42.6% and more common in MSA-C than in MSA-P. Conclusions: Increasing awareness of various motor and non-motor symptoms may assist clinicians to make an early, accurate diagnosis and to improve management of patients with MSA. We suggest that the diagnostic accuracy can be improved if these features are appropriately reflected in the new diagnostic criteria for MSA. |
Databáze: | OpenAIRE |
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