HER2 status in elderly women with breast cancer
| Autor: | Hemasri Tokala, Sainan Wei, Nikolay V. Dimitrov, Priyank Patel, Heather Laird-Fick, Joseph C. Gardiner |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Receptor ErbB-2 medicine.drug_class medicine.medical_treatment Breast Neoplasms Breast cancer Internal medicine Biomarkers Tumor medicine Humans skin and connective tissue diseases Prospective cohort study In Situ Hybridization Fluorescence Aged Retrospective Studies Aged 80 and over Gynecology Univariate analysis business.industry Carcinoma Ductal Breast Lumpectomy Age Factors medicine.disease Receptors Estrogen Hormone receptor Estrogen Biomarker (medicine) Female Geriatrics and Gerontology Receptors Progesterone business Mastectomy |
| Zdroj: | Journal of Geriatric Oncology. 4:362-367 |
| ISSN: | 1879-4068 |
| Popis: | Objectives HER2 (human epidermal growth factor receptor 2) is an important biomarker in breast cancer, but its prevalence in elderly women is not well established. Previous studies reported HER2 status based on either immunohistochemistry (IHC) or fluorescent in situ hybridization (FISH) interchangeably. However, the tests may give discordant results. We report the prevalence of HER2 amplification in elderly women using only FISH. Materials and Methods We retrospectively identified women 65years and older undergoing core biopsy, lumpectomy or mastectomy for primary breast malignancy at a single institution between 2009 and 2011. Data collected included age, histopathological type, hormone receptor status, and HER2 status. Descriptive statistics were performed using SAS Software, Version 9.2. Results One hundred fifty-eight women were included in the study. Most had invasive ductal carcinoma (74.7%), and were positive for either estrogen (ER) or progesterone (PgR) receptors (82.3% and 70.0%, respectively). Only 17% were negative for both ER and PgR; 11.4% were triple negative. Nineteen samples (12.0%) were positive for HER2. In univariate analyses, hormone receptor and HER2 status did not vary with age. When stratified by age, 60% of women with hormone receptor/HER2 positive tumors were younger than 70years, compared with 22.2–33.3% of women in other subgroups. The difference was not statistically significant (p=0.20). Conclusion This study adds to the knowledge of the biology of breast cancer in elderly women. Triple negative tumor incidence was similar to that previously reported for women under 70years old, but HER2 positive tumors were less common. Additional prospective studies are needed to confirm our findings. |
| Databáze: | OpenAIRE |
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