Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study

Autor:	Tom Florian Ulmer, Ulf P. Neumann, Rolf Rossaint, Michaël De Becker, Christian Trautwein, Anne Andert, Anna B. Roehl, Mare Mechelinck, Alexander Koch, Marc Hein, Theresa H. Wirtz, Sandra Hamada, Bianca Hartmann
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	cardiac systolic function medicine.medical_specialty medicine.medical_treatment lcsh:Medicine Speckle tracking echocardiography 030204 cardiovascular system & hematology Liver transplantation Single Center Article 03 medical and health sciences Liver disease 0302 clinical medicine Internal medicine medicine echocardiography Subclinical infection Ejection fraction Proportional hazards model business.industry lcsh:R General Medicine medicine.disease dobutamine stress test Cardiology cirrhotic cardiomyopathy outcome Portal hypertension 030211 gastroenterology & hepatology business strain analysis
Zdroj:	Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 2616, p 2616 (2020) Volume 9 Issue 8
ISSN:	2077-0383
Popis:	Speckle tracking echocardiography enables the detection of subclinical left ventricular dysfunction at rest in many heart diseases and potentially in severe liver diseases. It could also possibly serve as a predictor for survival. In this study, 117 patients evaluated for liver transplantation in a single center between May 2010 and April 2016 with normal left ventricular ejection fraction were included according to clinical characteristics of their liver disease: (1) compensated (n = 29), (2) clinically significant portal hypertension (n = 49), and (3) decompensated (n = 39). Standard echocardiography and speckle tracking echocardiography were performed at rest and during dobutamine stress. Follow-up amounted to three years to evaluate survival and major cardiac events. Altogether 67% (78/117) of the patients were transplanted and 32% (31/96 patients) died during the three-year follow-up period. Global longitudinal strain (GLS) at rest was significantly increased (became more negative) with the severity of liver disease (p < 0.001), but reached comparable values in all groups during peak stress. Low (less negative) GLS values at rest (male: > &minus 17/female: > 18%) could predict patient survival in a multivariate Cox regression analysis (p = 0.002). GLS proved valuable in identifying transplant candidates with latent systolic dysfunction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31010510ae4464e42569659eec156a23 http://europepmc.org/articles/PMC7464171 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.