Evaluation of 99mTc-Cefuroxime axetil for imaging of inflammation
| Autor: | Osman Yilmaz, Perihan Ünak, B. Seyitoglu, Kubra Durkan, H. Baskan, F. Yurt Lambrecht |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Biodistribution business.industry medicine.drug_class Health Toxicology and Mutagenesis Antibiotics Public Health Environmental and Occupational Health Inflammation Post injection Pollution Analytical Chemistry Urinary excretion Nuclear Energy and Engineering Medicine Radiology Nuclear Medicine and imaging Life saving medicine.symptom business Cefuroxime Spectroscopy medicine.drug Clearance |
| Popis: | Localizing and distinguishing the "infection" in body sites are very important and life saving processes. Scintigraphic detections may help to determine the sites of inflammation and infection. At this point, nuclear medical imaging may proceed one step further and be helpful to localize and distinguish the inflammation. The radiolabeled antibiotic Tc-99m-Cefuroxime axetil was assessed as an infection imaging agent in a rat model. In this study, Tc-99m-Cefuroxime axetil was examined in localizing the normal, sterile inflamed, and septic inflamed rat muscle tissues, and also in distinguishing each of them. The biodistribution data show that Tc-99m labeled Cefuroxime axetil was retained in infectious areas. The retention was better in septic inflamed (S. aureus) area than sterile inflamed area. The clearance of the labeled antibiotic from other tissues is rapid on the contrary to its clearance from the septic area. Target/non-target ratio shows a good value of 2.5 at 4-hour post injection when the activity of the other organs is cleared by urinary excretion. |
| Databáze: | OpenAIRE |
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