DPP6 Loss Impacts Hippocampal Synaptic Development and Induces Behavioral Impairments in Recognition, Learning and Memory
| Autor: | Jonathan G. Murphy, Jakob J. Gutzmann, Heather A. Cameron, Dax A. Hoffman, Ya-Xian Wang, Lin Lin, Ronald S. Petralia, Daniel Abebe, Rose-Marie Karlsson |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Dendritic spine neurodevelopment Hippocampus Morris water navigation task Motility DPP6 autism spectrum disorder Hippocampal formation Biology Dendritic filopodia lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine Spatial learning learning and memory Brain weight Neuroscience lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030217 neurology & neurosurgery Original Research |
| Zdroj: | Frontiers in Cellular Neuroscience Frontiers in Cellular Neuroscience, Vol 12 (2018) |
| ISSN: | 1662-5102 |
| Popis: | DPP6 is well known as an auxiliary subunit of Kv4-containing, A-type K+ channels which regulate dendritic excitability in hippocampal CA1 pyramidal neurons. We have recently reported, however, a novel role for DPP6 in regulating dendritic filopodia formation and stability, affecting synaptic development and function. These results are notable considering recent clinical findings associating DPP6 with neurodevelopmental and intellectual disorders. Here we assessed the behavioral consequences of DPP6 loss. We found that DPP6 knockout (DPP6-KO) mice are impaired in hippocampus-dependent learning and memory. Results from the Morris water maze and T-maze tasks showed that DPP6-KO mice exhibit slower learning and reduced memory performance. DPP6 mouse brain weight is reduced throughout development compared with WT, and in vitro imaging results indicated that DPP6 loss affects synaptic structure and motility. Taken together, these results show impaired synaptic development along with spatial learning and memory deficiencies in DPP6-KO mice. |
| Databáze: | OpenAIRE |
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